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We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis(MS)by ELISA,by radioimmune assay,or by radioimmune precipitation techniques.Immunoblot studies for HTLV-I- specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases.We did not find seroreactivity to HIV-1 or to the distantly related retrovirus,caprine arthritis encephalitis virus(CAEV).These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I,HIV-1,or CAEV. |
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